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There are several ways to accomplish this. To set a few registers or bits you can place Set Bit or Set Word objects on the common window (window #4). These objects have an option for Set On when window opens: Because the common window is always visible objects placed on this screen will be triggered once when the project starts. Another option is to use a macro. The SetData function can be used to write directly to PLC registers: And the macro editor includes an option to Execute one time when HMI starts:

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